According to my wife's doctor many of his patients with HH also have a mutation on their MTHFR gene. This makes it so they cannot break down vitamin B12 (folate?) correctly. Because of this he says we should be taking a methalated form of B12 folic acid. I need to do some research on this and will report on it. I am hoping my 23andme test will cover the MTHFR gene! Those results should be in for us in about 3 weeks. He also suggested testing CD4 and CD8 cells for anyone with HH to see the overall effect the disease has had on us. He has some very interesting ideas on HH partially because he has a mutation as well, but it is not as impacting as HH. He further commented on thyroid involvement being very important to identify with HH and also that cortisol which is typically produced in 'fight or flight' scenarios and has a drastic impact on digestion. Apparently HH affecting thyroid can cause elevated cortisol which affects the ability to process our food and get the nutrients.
Turns out that 23andme tests for this but does not report it. One needs to use these links:
https://www.23andme.com/you/explorer/snp/?snp_name=Rs1801133
https://www.23andme.com/you/explorer/snp/?snp_name=Rs1801131
The first link correlates to the C677T mutation with an A result in the DNA resulting in the T mutation in the protein. The second link correlates to the A1298C mutation with a G result in the DNA resulting in the C mutation in the protein. So if 23andme reports AA on the first link, then you are homozygous for the C677T mutation and should research what that means for you even though it is not described with the 23andme results!
Turns out that 23andme tests for this but does not report it. One needs to use these links:
https://www.23andme.com/you/explorer/snp/?snp_name=Rs1801133
https://www.23andme.com/you/explorer/snp/?snp_name=Rs1801131
The first link correlates to the C677T mutation with an A result in the DNA resulting in the T mutation in the protein. The second link correlates to the A1298C mutation with a G result in the DNA resulting in the C mutation in the protein. So if 23andme reports AA on the first link, then you are homozygous for the C677T mutation and should research what that means for you even though it is not described with the 23andme results!